Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow. The anticancer activity is induced by xanthones such as alpha-, beta-, and gamma-mangostin which are major constituents of the pericarp of mangosteen fruits. In order to obtain the biological active compound, α-mangostin, from the traditional native mangosteen (Garcinia mangostana L.), an extraction.

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The mice in the control group received the vehicle 0. Immunohistochemical analysis was also performed to examine the expression of Ki, the protein responsible for the rate of tumor growth Fig. Tumor size was measured using Vernier calipers Mitutoyo, Kawasaki, Japan. B The sub-G1 fraction was assessed by PI staining and flow cytometry. A comparative study of effects of aversectin C abamectin and ivermectin on apoptosis of rat thymo-cytes induced by radiation and dexamethasone.

In general, if apoptosis is induced in vitro and in vivoan increase in the sub-G1 population is observed along with DNA fragmentation 28 Targeting pMAPK in the ischaemic heart: The MAPK signaling pathway is a core factor controlling various pathways, including cell growth, proliferation, segmentation and apoptosis.


To identify cleaved c -caspase-3 protein, immunohistochemcal staining was performed on tumor tissues collected from mouse xenografts as described in the Material and methods.

Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Apoptotic bodies were stained with DAPI.

Mangosteen Garcinia mangostana L. This is an open access article distributed under the terms of Creative Commons Attribution Mangosin. Bao Q and Shi Y: In some studies, it was reported that several naturally derived substances induce apoptosis and inhibit cancer cell growth 21 — International Journal of Molecular Medicine, 37, Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus.


A clinicostatistical analysis of oral cancer patients for recent 8 years. Thus far, various xanthones have been found in fruit, fruit skin, tree bark, moss and mold, and approximately 40 different xanthones have been found in the mangosteen fruit Early diagnosis of oral cancer. It is therefore necessary to find naturally-derived substances to serve as anticancer drugs that are capable of specifically targeting cancer cells, with limited side-effects and potent anticancer effects.

Each group is controlled by its own pathway and performs distinct functions. Medicinal properties of mangosteen Garcinia mangostana. April Volume 37 Issue 4. Representative staining profiles for 10, cells per experiment are shown. Surgical therapies, radiation therapies, medications and other current treatments for oral cancer are associated with a low treatment efficacy and severe adverse effects; thus, in general, oral cancer has a poor prognosis.

A marked difference between the treated and control groups was observed beginning on day 8 following treatment Fig. Statistical significance was determined by the Dunnett’s t-test. Differences between mean values for the individual groups were assessed by one-way analysis of variance ANOVA with Dunnett’s t-tests.

A Ki antibody was used to differentiate nuclei in proliferating cells G1, S, G2 and M phases from those in resting cells, as previously described Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways.

A Membranes incubated with the anti-Bax antibody. Xanthones from mangosteen extracts as natural chemopreventive agents: Caspases are key factors that control apoptosis and are involved in a common pathway of various apoptotic signals.


Donovan M and Cotter TG: Chemical constituents of Garcinia mangostana.

Mangostin | C24H26O6 – PubChem

Bcl-2 family proteins control membrane permeability and are located in the mitochondrial membrane or move to the mitochondrial membrane to induce apoptotic cell death Bax and Bad are pro-apoptotic factors that promote apoptosis, whereas Bcl-2 is an anti-apoptotic factor 31 Change of the invasiveness with selective Cox-2 inhibition in mangosstin oral squamous cell carcinoma cell Line, KB: Data analysis was performed using ImageJ software by measuring the integrated band densities following background subtraction.

DAPI staining was performed to identify the morphological apha associated with nuclear and chromosomal condensation. Proliferation, cell cycle and apoptosis in cancer.

A significant difference in tumor volume emerged in the control group from day 8 onwards following treatment. This article is mentioned in: Fluorescence signals were visualized using a fluorescence microscope BX41; Olympus Co. Moreover, the number of viable cells decreased in a concentration-dependent manner.


Caspases are further classified into initiator and effector caspases. Moreover, the observed increases were concentration-dependent.

Significance was determined by Dunnett’s manyostin. Both caspase-3 and -9 were activated, as evidenced by the increased levels of the respective cleaved appha, as well as PARP segmentation Fig. The apoptotic cells were analyzed quantitatively by flow cytometry to determine whether the morphological changes observed in the DAPI-stained chromosomes were caused by apoptosis.

B Membranes incubated with the anti-Bcl-2 antibody.

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